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PDE5 Inhibition:
phosphodiesterase type 5 (PDE5)
:
By inhibiting PDE5, Cialis allows for increased levels of cGMP, which relaxes smooth muscle tissue and widens blood vessels in the penis, leading to improved blood flow and a stronger, sustained erection.
:
:
Cialis has a longer half-life than other similar medications, meaning it remains active in the body for up to 36 hours
30 minutes to 2 hours36 hours
:
30 to 60 minutes.
2 hours
:
36 hours
:
: Higher doses (10-20 mg) tend to act faster than lower doses (5 mg daily dose).
30 minutes to an hour before sexual activity and consider its long-lasting effect if taken in advance.
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If you are taking tadalafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph. There are two different ways to take tadalafil, either daily or on an as needed basis. Talk to your doctor about which dosing schedule is right for you. Tadalafil is sometimes taken as needed, usually at least 30 minutes before sexual activity and not more often than once every 24 hours. Your doctor will help you decide the best time for you to take tadalafil before sexual activity. Tadalafil is also sometimes taken once a day every day without regard to timing of sexual activity. You may attempt sexual activity at any time between doses. If you are taking tadalafil on a regular schedule, take it at around the same time every day. If you have certain health conditions or are taking certain medications, your doctor may tell you to take tadalafil less often or may prescribe a lower dose to be taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tadalafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
tell your doctor if you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure whether any of your medications contain nitrates. Your doctor will probably tell you not to take tadalafil if you are taking nitrates.
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